ProFound AI
ProFound AI® Risk is the first and only clinical decision support tool that provides an accurate
two-year, breast cancer risk estimation that is truly personalized for each woman, based only on a
screening mammogram. 1
The easy-to-implement solution provides superior insights 1 that empower clinicians to tailor a
woman’s breast screening regimen and potentially identify cancers earlier.
Personalized Screening Made Easy with ProFound AI Risk
ProFound AI Risk is a clinical decision support tool that utilizes ProFound AI breast feature complexity
findings, automated breast density, and age in order to calculate a woman’s short-term, absolute risk of
breast cancer.
The risk score assists physicians in their personalization of a woman’s screening and surveillance
regimen, which may include screening frequency adjustment, supplemental screening, genetic testing or
risk reduction strategies.
ProFound AI Risk can be seamlessly implemented in a mammography facility. All that is needed is a
standard bilateral two-view full-field digital mammogram.
References
1.iCAD data on file. FDA filing: K203822. Standalone performance varies by vendor. FDA Cleared and CE Marked.
2.Conant, E et al. (2019). Improving Accuracy and Efficiency with Concurrent Use of Artificial Intelligence for Digital Breast Tomosynthesis. Radiology: Artificial Intelligence. 1 (4). Accessed via https://pubs.rsna.org/doi/10.1148/ryai.2019180096
3.Compared to previous versions of the software, the ProFound AI 3.0 algorithm offers up to a 10% improvement in specificity performance, up to 1% improvement in sensitivity, and up to 40% faster processing on the new PowerLook platform.
2.Conant, E et al. (2019). Improving Accuracy and Efficiency with Concurrent Use of Artificial Intelligence for Digital Breast Tomosynthesis. Radiology: Artificial Intelligence. 1 (4). Accessed via https://pubs.rsna.org/doi/10.1148/ryai.2019180096
3.Compared to previous versions of the software, the ProFound AI 3.0 algorithm offers up to a 10% improvement in specificity performance, up to 1% improvement in sensitivity, and up to 40% faster processing on the new PowerLook platform.
How does ProFound AI work?
The ProFound AI algorithm rapidly and accurately analyzes each individual image or slice and identifies potentially malignant lesions. Trained
with one of the largest available 3D image datasets, ProFound AI provides radiologists with crucial information, such as lesion Certainty of
Finding and Case Scores, which assists in prioritizing caseload, clinical decision-making and may help to reduce physician burnout.
ProFound AI for Digital Breast Tomosynthesis (DBT) is FDA cleared to offer superior performance and sensitivity to support radiologists in the
fight against breast cancer with an unrivaled accuracy of detection.
Superior AUC Performance with ProFound AI Risk
Initial research demonstrates ROC AUC of 0.73,2 a significant AUC improvement over the Tyrer-Cuzick and NCI Gail risk models.1 ProFound AI Risk is designed to aid physicians in optimizing individualized screening in order to improve efficiencies and outcomes.
Proven Solution Uniquely Positioned for Personalized Screening
ProFound AI Risk offers proven results that rapidly provide physicians and patients with an accurate two-year absolute breast cancer risk score and risk category (low, general, moderate and high). 1
The field of mammography is moving from age-based screening to more individualized risk-based
screening. ProFound AI Risk is a leading-edge solution that enables clinicians to easily adapt to evolving
screening practices and personalized patient care.
Benefits to the Patient
- Assists in early detection, which can lead to improved outcomes
- Reduces false positives/recalls
- Improves detection accuracy
Benefits to the Facility
- Enhances patient care with improved detection technology
- Improves workflow efficiency
- Increases diagnostic confidence
- Supports mixed tomosynthesis environments
Certainty of Finding and Case Scores
The ProFound AI algorithm is trained to detect malignant soft tissue densities and calcifications.
Certainty of Finding and Case Scores are assigned to each detection and each case respectively.
Certainty of Finding and Case Scores are relative scores computed by the ProFound AI algorithm and
represent the algorithm’s confidence that a detection or case is malignant.
The scores are represented on a 0% to 100% scale. A higher score indicates a higher level of confidence
in the malignancy of the detection or case. The Certainty of Finding and Case Scores serve as a guide to
the interpreting radiologist to aid in determining if a suspicious finding or case needs further workup.
Certainty of Finding Score
Certainty of Finding Scores are assigned to each detection identified by the ProFound AI algorithm. The
score represents how confident the algorithm is that the detection is malignant. Certainty of Findings
scores assist in prioritizing caseload and clinical decision-making.
Case Score
Case Scores are assigned to each case by the ProFound AI algorithm. The Case Score represents how
confident the algorithm is that a case is malignant. All cases, including those without detections, will be
assigned a Case Score. Clinicians may use this Case Score information to gain a sense of case complexity,
which may be useful for prioritizing the reading work list if supported by the specific work list provider.
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